Esomeprazole resolves chronic heartburn in patients without erosive oesophagitis
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چکیده
منابع مشابه
Esomeprazole versus pantoprazole for healing erosive oesophagitis.
The aim of this study was to compare the efficacy of esomeprazole and pantoprazole with regard to healing and relief from gastroesophageal reflux disease-related symptoms. I this multicentre, randomized, single-blind study 180 patients (ITT population) diagnosed with endoscopically proven GERD grade A,B,C received esomeprazole (40 mg once daily (o.d.), n = 90) orpantoprazole (40 mg o.d., n = 90...
متن کاملFunctional heartburn and non-erosive reflux disease.
Gastroesophageal reflux disease (GERD) is a common disorder in Western countries. For many years our attention has been focused on patients with erosive esophagitis, but in recent times we have realized that endoscopy-negative reflux disease is the most common presentation of this illness, affecting up to 70% of these individuals. Patients with the non-erosive form (NERD) are a heterogeneous gr...
متن کاملRelationship between esomeprazole dose and timing to heartburn resolution in selected patients with gastroesophageal reflux disease
OBJECTIVE To increase response rates to therapy by increasing the dosage of proton pump inhibitor (PPI) therapy in patients with gastroesophageal reflux disease (GERD) whose symptoms are predominantly associated with acid reflux. METHODS In this double-blind, randomized, proof-of-concept study, 369 patients with GERD and moderate heartburn lasting ≥three days/week, a history of response to an...
متن کاملSymptom-relieving effect of esomeprazole 40 mg daily in patients with heartburn.
BACKGROUND To assess symptom relief in patients with heartburn following treatment with esomeprazole 40 mg daily. METHODS Patients with heartburn (for > or = 6 months) were assessed in this double-blind, multicenter study. After a 3-day single-blind placebo run-in, 440 patients were randomized to esomeprazole 40 mg o.d., esomeprazole 20 mg b.i.d. or placebo for 14 days. Heartburn symptoms wer...
متن کاملSystematic review: the efficacy of intermittent and on-demand therapy with histamine H2-receptor antagonists or proton pump inhibitors for gastro-oesophageal reflux disease patients.
AIM To perform a systematic review on the efficacy of intermittent and on-demand therapy with either histamine H2-receptor antagonists or proton pump inhibitors for patients with erosive oesophagitis or symptomatic heartburn. METHOD We conducted randomized-controlled trials of non-continuous therapy in gastro-oesophageal reflux disease patients. RESULTS Fourteen studies met inclusion criter...
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ژورنال
عنوان ژورنال: Alimentary Pharmacology & Therapeutics
سال: 2003
ISSN: 0269-2813
DOI: 10.1046/j.1365-2036.2003.01771.x